College of Science and Mathematics - Mindanao State University-Iligan Institute of Technology
Kynurenine, xanthurenic acid and anthranelic acid are breakdown products of the metabolism of L-tryptophan in the liver. These were screened for antigenotoxic activity in the bone marrow and germ cells of mice treated with known mutagens such as methyl-methane sulfonate (MMS) and dimethylnitrosamine (DMN). The three compounds reduced both the formation of micronucleated polychromatic erythrocytes in bone marrow cells and the number of dead implants in mice treated with the mutagens and therefore may be classified as antigenotoxic agents. The indole ring of L-tryptophan is not necessary for its antigenotoxic activity. It is proposed that the carboxylate group and the aromatic ring of tryptophan and its metabolites may be responsible for the antigenotoxix activities exhibited by these compounds.